3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets
نویسندگان
چکیده
منابع مشابه
Somatic Mutations in Protein Domains Protein Domain Hotspots Reveal Functional Mutations across Genes in Can- cer
In cancer genomics, frequent recurrence of mutations in independent tumor samples is a strong indication of functional impact. However, rare functional mutations can escape detection by recurrence analysis for lack of statistical power. We address this problem by extending the notion of recurrence of mutations from single genes to gene families that share homologous protein domains. In addition...
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The transformation of a normal cell into a cancer cell takes place through a sequence of a small number of discrete genetic events, somatic mutations: thus, cancer can be regarded properly as a genetic disease of somatic cells. The analogy between evolution of organisms and evolution of cell populations is compelling: in both cases what drives change is mutation, but it is Darwinian selection t...
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ژورنال
عنوان ژورنال: Genome Medicine
سال: 2017
ISSN: 1756-994X
DOI: 10.1186/s13073-016-0393-x